Free afternoon in Amsterdam

I am planning to take the Brussels to Amsterdam river cruise in 2013. I noticed that there is a free afternoon in Amsterdam. I also understand that Tauck provides a shuttle to Museumplein in the center of the city. I would like to see the Anne Frank House and am wondering if anyone has done that on the free afternoon. I know that I would need to purchase advance tickets so I need to know how would I get there and is there enough time to go there, see the house and return for the shuttle. Thanks.

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